A proteome profiling carried out on BRCA1-mutated W780 and W0069 cells evidenced that CDDO-Im significantly increases caspase 3 cleavage, increases heat shock protein 70 (HSP70), and decreases in claspin, BIRC5, B-cell Lymphoma-extra-large, and BCL2 associated agonist of cell death. The gene discussed is BRCA1; the disease is B-cell non-Hodgkin lymphoma.