IGHE and asthma: Individuals with asthma exhibit activated Th2 lymphocytes that increase the production of cytokines responsible for initiating and maintaining the inflammatory process, with IL-4, along with IL-5, IL-13, and CCL11 (eotaxin-1), playing important roles in recruiting eosinophils to the tissue [32], resulting in the production of immunoglobulin E (IgE) antibodies.