Very recently, some authors revealed that the inhibition of XIST fine-tuned cell proliferation and the apoptosis rate by regulating the expression levels of p-p65 and p-IκBα NF-KB in human osteosarcoma cells and in rheumatoid arthritis fibroblast-like synoviocytes [45,58]. The gene discussed is NFKBIA; the disease is rheumatoid arthritis.