NEDD4L and diabetic peripheral angiopathy: Lastly, Gao et al. [78] applied the SHENQI compound (composed of several medicinal plants, including Rehmannia glutinosa, hawthorn, raw radix, and ginseng) from traditional Chinese medicine to a mouse model of diabetic microangiopathy to evaluate whether NEDD4L targeting could protect against vascular calcification during diabetic angiopathy.