However, it is known that the overexpression of NEDD4L-promoted protein kinase b (Akt) favors the phosphorylation of endothelial nitric oxide synthase (eNOS), which can impair the action of this enzyme, ultimately favoring the formation of atherosclerosis plaques under hyperlipidemic conditions [53,74,75]. The gene discussed is NOS3; the disease is atherosclerosis.