This was evidenced using longitudinal measurements of anti-nephrin autoantibodies in select subcohorts of 18 children with INS, 13 adults with MCD, and 5 adults with primary FSGS, founding that a negative anti-nephrin autoantibody titre was predictive of remission (defined by a urine protein-to-creatinine ratio of <0.3 g/g) and a reduction in proteinuria to a urine protein-to-creatinine ratio of <3.5 g/g in over 90% of subjects. Here, NPHS1 is linked to focal segmental glomerulosclerosis.