Our anti-SIRPα antibodies alone did not augment macrophage phagocytic activity, a finding consistent with results from other groups demonstrating that anti-SIRPα antibody (BMS-986351) treatment alone exhibits limited efficacy [8], which may be attributed to the suboptimal interaction between SIRPα on macrophages and CD47 expressed on the colorectal tumor cells used in our study. This evidence concerns the gene SIRPA and colorectal neoplasm.