WNK2 and neoplasm: From a biological mechanism perspective, the HGF/MET signaling axis can activate various downstream signaling pathways, such as rat sarcoma virus/rapidly accelerated fibrosarcoma, mitogen-activated protein kinase kinase/extracellular signal-regulated kinase, phosphatidylinositol 3-kinase/protein kinase B, and wingless-related integration site/β-catenin pathways, thereby participating in key growth processes such as tumor cell proliferation, survival, invasion, migration, and drug resistance [53].