POMC and Prader-Willi syndrome: RNA sequencing of the hypothalamus from individuals with PWS showed that upregulated genes overlapped with the mouse agouti-related peptide (AgRP) neurons, mainly located within the AC and activated by hunger, while downregulated genes overlapped with the expression profile of proopiomelanocortin (POMC) neurons, which in the AC are activated by feeding and satiety [5].