MAPK8 and neurodegenerative disease: However, this pathway is poorly studied in neurodegenerative diseases, based on our study, using in silico analysis, we identified several molecules involved in this process BAK1, HSPA1B, MAPK8, NFE2L2, SEC23A, UBE2D3, UBQLN1 and XBP1 which could play an important role in SCA7.