However, this pathway is poorly studied in neurodegenerative diseases, based on our study, using in silico analysis, we identified several molecules involved in this process BAK1, HSPA1B, MAPK8, NFE2L2, SEC23A, UBE2D3, UBQLN1 and XBP1 which could play an important role in SCA7. The gene discussed is HSPA1B; the disease is neurodegenerative disease.