Subsequently, with these proteins related to pulmonary diseases, we found three potential mediation pathways including indirect effect of EFEMP1 on COPD via FEV1/FVC, an indirect effect of MAPK3 on Asthma via FEV1/FVC and an indirect effect of NPNT on COPD risk via FEV1/FVC. This evidence concerns the gene MAPK3 and chronic obstructive pulmonary disease.