As shown in Figure 5, compared to the control group, the tumor significantly decreased phosphorylated Akt and FOXO1 levels while increasing phosphorylated NF-κB p65 expression, which represents the activation of FOXOs and NF-κB, respectively, in the gastrocnemius muscle (p < 0.01 or 0.001). The gene discussed is NFKB1; the disease is neoplasm.