They identified 32 proteins, including biglycan (BGN), collagen-type VI alpha 2 chain (COL6A2), collagen-type VIII alpha 1 chain (COL8A1), collagen-type XVIII alpha 1 chain (COL18A1), latent transforming growth factor beta-binding protein 2 (LTBP2), lumican (LUM), matrilin 2 (MATN2), matrilin 3 (MATN3), mucin 6 oligomeric mucus/gel-forming (MUC6), proline/arginine-rich end leucine-rich repeat protein (PRELP) and tenascin C (TNC), which were only expressed in FECD patient when compared with Descemet’s membrane of the normal control. The gene discussed is MATN2; the disease is Fuchs endothelial corneal dystrophy.