TCF4 and Fuchs endothelial corneal dystrophy: Due to the similarity of alternative splicing patterns between the non-symptomatic and the FECD group with intronic TNR expansion in TCF4, the authors hypothesized that changes in gene expression in endothelial cells with pathologic intronic TNR expansion in TCF4 are present long before the beginning of FECD symptoms, which could be an important resource to identify candidate biomarkers for earlier diagnosis and treatment of FECD [75].