Angelbello et al. [104] obtained corneal endothelial cells from FECD patients and incubated them with an RNA-targeting small molecule, which was designed to bind to the toxic repeat-expansion region of the poly(CUG)n TCF4 transcript, facilitating excision and further degradation by the nuclear RNA exosome complex. This evidence concerns the gene TCF4 and Fuchs endothelial corneal dystrophy.