Several groups have confirmed genetic variations (SNPs, mutations, and trinucleotide repeat (TNR) expansion) in candidate genes, including COL8A2, TCF4, SLC4A11, AGBL1, ZEB1, LOXHD1, XRCC1, FAS, and FASLG, to be in an association with early-onset and/or late-onset FECD [30,39,41,42,43,44,45,46,47,48]. Here, COL8A2 is linked to Fuchs endothelial corneal dystrophy.