First, they analyzed only their own transcriptomics data, and three up- (named TCF4-283, TCF4-218 and TCF4-255) and two downregulated (TCF4-276 and TCF4-290) TCF4 isoforms were detected in FECD cases without intronic TNR expansion compared to controls. Here, TCF4 is linked to Fuchs endothelial corneal dystrophy.