SOD3 and Fuchs endothelial corneal dystrophy: As previously identified by transcriptomic analysis [81], De Roo et al. [82] used the immunohistochemical (IHC) staining of paraffin-embedded corneal endothelial cells and confirmed a higher expression of alpha-smooth muscle actin (ACTA2), cytokeratin 7 (KRT7), superoxide dismutase 3 (SOD3) and the decreased expression of serpin peptidase inhibitor clade A member 3 (SERPINA3) in FECD compared to control group.