MAPK3 and renal cell carcinoma: In renal cancer (RCC), ATP-P2RX6 was reported to participate in the regulation of the Ca2+-mediated p-ERK1/2/MMP9 signaling pathway to enhance the migration and invasion of RCC cells, while METTL14/m6A signaling can downregulate the translation of the P2RX6 protein [52].