The downregulation of METTL3 can significantly restrain liver metastasis in gastric cancer (GC) mouse models through the disruption of the m6A reader IGF2BP3-mediated enhancement of hepatoma-derived growth factor (HDGF) transcript stability, which plays a crucial role in tumor cell proliferation, migration, and angiogenesis [50]. This evidence concerns the gene IGF2BP3 and neoplasm.