In addition, the activation of the HDGF-PI3K-AKT-mTOR axis could also be inhibited after decreasing m6A through the disrupted Circ-CDYL biogenesis mediated by m6A/YTHDC1 and the m6A/hnRNPA2/B1-mediated active sorting of Circ-CDYL into exosomes, ultimately attenuating tumor malignancy [69]. This evidence concerns the gene HDGF and neoplasm.