In hepatoblastoma (HB), the knockdown of METTL3 notably decreased the expression and stability of CTNNB1 mRNA, which encodes β-catenin that binds to the TCF4/LEF1 transcription factor and activates target genes such as Jun, MYC, and CCND1, resulting in significant inhibition of HB cell proliferation and colony formation [47]. Here, TCF4 is linked to hemoglobin measurement.