Mechanistically, P300-mediated H3K27 acetylation activation in the promoter of METTL3 induced METTL3 transcription, which stimulated m6A modification and the IGF2BP3-enhanced stability of HDGF mRNA, which promoted tumor angiogenesis by activating GLUT4, ENO2 expression, and an increase in glycolysis in GC cells [50]. The gene discussed is HDGF; the disease is neoplasm.