PIK3CA and neoplasm: The Western blot analysis demonstrated that the decreased levels of phosphorylated AKT, PI3K, and mTOR (p-AKT, p-PI3K, and p-mTOR) in MARK3 overexpressing cells indicate that MARK3 may influence downstream survival signaling pathways, thereby impacting tumor behavior through modulation of the PI3K/AKT/mTOR pathway.