SCNN1B and gastric cancer: While the functional role of this gene in the UPR has yet to be investigated, increased expression of the homologous protein SCNN1B is a good prognostic factor in gastric cancer; at the molecular level, this protein was reported to initiate polyubiquitination of GRP78 to induce its proteasomal degradation, thereby downregulating the UPR to suppress malignant cell growth and metastasis [20].