Patients with pathological grade G2 exhibited a significantly lower proportion of tumor-infiltrating CD28+PD1−/CD8+ T cells compared to grade G1 patients (7.59% vs. 18.69%, p = 0.019), while no statistical difference was observed between grades G3 and G1 (9.56% vs. 18.69%, p = 0.052). This evidence concerns the gene CD28 and neoplasm.