CD28 and Lafora disease: Among stage I patients, those with LVSI (24.85% vs. 38.23%, p = 0.032) or MELF pattern invasion (23.68% vs. 38.22%, p = 0.024) had lower proportions of CD28+PD1−/CD8+ T cells in PBMC compared to those without these high-risk factors (Figure 2C).