Given the association of severe symptomatic hypoglycemia (tremors, sweating, and convulsions) and high insulin levels, the hypothesis of insulinoma was suggested and magnetic resonance imaging (MRI) of the abdomen was indicated, which identified a pancreatic nodule measuring 1.0 x 0.8 cm (Figure 1A), suggesting the diagnosis. The gene discussed is INS; the disease is pancreatic insulinoma.