Similar to the clinical osteomyelitis S. aureus strain UAMS-1, the USA300 methicillin-resistant strains, HFH 29568 and TCH 1516, stimulated a significant production of IL-6 and IFN-β by primary murine and human osteoblasts (Fig. 5A and B). This evidence concerns the gene IFNB1 and osteomyelitis.