While broad inhibition of cathepsins by E64d or specific inhibition of cathepsin L by SID 26681509 markedly reduced SARS-CoV-2 pseudovirus infection, inhibition of cathepsin B by CA-074 did not show any significant reduction in infection, indicating that cathepsin L plays a crucial role in SARS-CoV-2 entry (50). The gene discussed is CTSB; the disease is infection.