These DAMPs drive, activate, attract, and stimulate antigen‐presenting cells especially DCs through various pattern‐recognition receptors, ultimately cross‐presenting tumor antigens to NK cells and T cells, and activating specific immune responses.[22, 23] Studies have shown that the increased level of HMGB1 in blood after radiotherapy and chemotherapy is associated with a good prognosis in head and neck squamous cell carcinoma, and HMGB1 can be used to predict the outcome of malignant tumors.[35]. The gene discussed is HMGB1; the disease is head and neck squamous cell carcinoma.