CGAS and neoplasm: Cytoplasmic dsDNA, one of the crucial stimulators of innate immunity, can evoke type I IFN production through the cyclic GMP‐AMP synthase (cGAS)‐STING pathway.[31, 35] As PE38 induces apoptosis and ICD of tumor cells, we hypothesized that cytosolic DNA released from C5‐PE38‐treated cells may activate the STING pathway in antigen‐presenting cells (APCs).