RNF135 and intrahepatic cholangiocarcinoma: Here, in a small dataset (TCGA‐CHOL: ICC, n = 36; adjacent, n = 15), we found that 5 out of 8 MDMs (except DAB2IP, PTPN18, and RNF135) included in the COMET‐LR had a remarkably higher methylation level in ICCs compared to adjacent tissues (Figure S6, Supporting Information), which might be preliminary due to the small sample size.