These MDM‐associated genes are known to play crucial roles in tumorigenesis, specifically cell differentiation and proliferation, metabolism, cytokine signaling, and epithelial‐mesenchymal transition (summarized in Table S4, Supporting Information).[11, 12, 15] Further validation was implemented in The Cancer Genome Atlas‐Liver Hepatocellular Carcinoma (TCGA‐LIHC) cohort where methylation levels of HCC tissues were assessed by the HM450 microarray.[16] The probes closest to the 11 identified MDMs were analyzed. Here, SLURP1 is linked to hepatocellular carcinoma.