AFP and hepatocellular carcinoma: Hepatocellular carcinoma (HCC) stands as a critical global health concern, particularly in individuals afflicted with liver cirrhosis (LC) and/or hepatitis virus B/C infections (HVI).[1] The imperative for early detection is paramount, given that interventions at advanced stages often yield limited efficacy.[2] Existing diagnostic modalities, including alpha‐fetoprotein (AFP) and ultrasound, though widely utilized, are fraught with limitations, particularly in terms of accuracy.[3, 4]