We sought to further compare MDM‐based models with published scores (gender, age, Lens culinaris agglutinin‐reactive AFP, AFP, and des‐g‐carboxy‐pro‐thrombin score [GALAD], age, sex, AFP, and PIVKA‐II [ASAP], and Doylestown) for HCC early detection. The gene discussed is AFP; the disease is hepatocellular carcinoma.