AFP and cancer: With commonly used cut‐off values for AFP (20 ng/mL) and protein induced by vitamin K absence II (PIVKA‐II, 40 mAU/mL) in clinical settings,[18] the COMET‐LR identified 82.5% of AFP‐negative cancer cases and 74.2% of PIVKA‐II‐negative cancer cases (Figure 3B).