Parkin‐independent and non‐selective mitophagy pathways mediated by proteins such as Nix, FUNDC1, Bcl‐2‐L‐13, FKBP8, and Fis1 have been reported.[18, 21] Among these, 4D‐label‐free quantitative proteomic analysis revealed that Fis1 was the only protein with significantly downregulated expression in the aorta of mice exposed to 20 weeks of hyperglycemia (Figure5A). The gene discussed is BNIP3L; the disease is Hyperglycemia.