Macrophage content (Figure 9G,H) and the smooth muscle cell content (Figure 9I,J) in atherosclerotic lesions were higher in mice transduced with Fis1 shRNA starting from 6 weeks of hyperglycemia exposure and further aggravated following 20 weeks of hyperglycemia exposure, compared to the control shRNA group. Here, FIS1 is linked to Hyperglycemia.