PRKN and Hyperglycemia: Parkin‐independent and non‐selective mitophagy pathways mediated by proteins such as Nix, FUNDC1, Bcl‐2‐L‐13, FKBP8, and Fis1 have been reported.[18, 21] Among these, 4D‐label‐free quantitative proteomic analysis revealed that Fis1 was the only protein with significantly downregulated expression in the aorta of mice exposed to 20 weeks of hyperglycemia (Figure5A).