Based on the transcriptomic data of clinical chordoma tissues, RAB3B showed a high correlation with stemness markers (Figure S4I, Supporting Information), such as TBXT (R = 0.85, p = 5e–15), OCT4 (R = 0.5, p = 0.00016) and NANOG (R = 0.41, p = 0.0027). Here, POU5F1 is linked to chordoma.