Altogether, our data not only indicate a novel mechanism of RAB3B in regulating mTORC1 signaling by interacting with DUSP12 and blocking its dephosphorylation of p‐S6 at S235/236, but also provide a therapeutic strategy of mTORC1‐targeted therapy for advanced chordoma patients with aberrant RAB3B/p‐S6 hyperactivation (Figure9). This evidence concerns the gene RPS6 and chordoma.