The results revealed that chordoma patients with high expression of RAB3B and p‐S6 (S235/236) had the poorest prognosis, while patients with low RAB3B and p‐S6 (S235/236) expression had the longest PFS (p = 9.349e–06, Figure8A) and OS (p = 8.202e–06, Figure 8B). The gene discussed is RAB3B; the disease is chordoma.