RAB3B and neoplasm: Based on the CH22‐bearing tibia model, knockdown of RAB3B markedly decreased the tumor volume (TV) in nude mice and rescue experiment reinforced the chordoma formation (TV of CH22sgCtrl+Vec: 1.1634 ± 0.1984 cm3; TV of CH22sgRAB3B+Vec: 0.3215 ± 0.1238 cm3; TV of CH22sgRAB3B+Flag‐RAB3B: 1.2096 ± 0.1805 cm3; Figure 2H).