Given that COPD is associated with accelerated lung tissue aging,[19] we further examined Prmt1 expression in the context of aging by analyzing previously published single‐cell sequencing (scRNAseq) datasets from young and aged mouse lungs (Figure S3A–E, Supporting Information).[20] This analysis revealed a reduction of Prmt1 expression in aged lungs, with the most decrease observed in ECs, whereas other Prmts generally showed low expressions with no significant changes between young and aged mice. This evidence concerns the gene PRMT1 and chronic obstructive pulmonary disease.