In contrast to cytotoxic T lymphocyte antigen 4 (CTLA‐4) or PD‐1, which is predominantly expressed in immune cells, PD‐L1 is expressed in cancer cells and macrophages, playing a crucial role in suppressing immune surveillance.[19] This study elucidates the mechanisms by which chemotherapeutic drugs induce PD‐L1 expression, leading to the initiation of T‐cell immunosuppression by cancer cells. This evidence concerns the gene CD274 and cancer.