After treatment of myeloma cells with chemotherapeutic drugs such as bortezomib or melphalan, DNA damage is induced, activating the cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway. The gene discussed is STING1; the disease is plasma cell myeloma.