discovered that histone methyltransferase mixed lineage leukemia 1 (MLL1) directly binds to the PD‐L1 promoter, catalyzing trimethylation of histone H3 lysine 4 (H3K4me3) and activating PD‐L1 transcription in tumor cells.[11] MYC proto‐oncogene (MYC) is an oncogenic factor overexpressed in various tumors, and is involved in the regulation of PD‐L1 expression in multiple cancers.[12]. This evidence concerns the gene CD274 and neoplasm.