For instance, TAMs and cancer‐associated fibroblasts (CAFs) are known to secrete cytokines and growth factors that can modulate PD‐L1 expression on cancer cells and contribute to the establishment of an immunosuppressive microenvironment.[33, 37] Whether chemotherapy drugs influence the regulatory roles of TAMs and CAFs in shaping the immunosuppressive microenvironment of myeloma is a compelling question that deserves in‐depth exploration in future studies. This evidence concerns the gene CD274 and plasma cell myeloma.