IRF3 and neoplasm: For instance, TBK1 and TBK binding protein 1 (TBKBP1) have been shown to regulate tumor‐mediated immunosuppression by facilitating epidermal growth factor (EGF)‐induced PD‐L1 expression.[28] Additionally, the STING–TBK1 axis triggers an innate immune response by phosphorylating IRF3, IRF7, or NF‐κB.