Beyond intrinsic tumor factors, the tumor microenvironment's excessive secretion of pro‐inflammatory cytokines, such as IFN‐γ,[16] tumor necrosis factor α (TNF‐α),[16] and interleukins (IL),[17] can induce PD‐L1 expression in tumor cells, thereby facilitating immune escape. The gene discussed is CD274; the disease is neoplasm.