Based on previous clinical observational studies, a higher NIHSS score, lower ASPECTS (Alberta Stroke Program Early CT Score), massive cerebral infarction, cardiogenic cerebral embolism, and some biomarkers, including MMPs, cellular fibronectin, and occludin, may contribute to s‐HT occurrence for ischemic stroke [9, 20]. The gene discussed is OCLN; the disease is ischemic stroke.