The ubiquitous presence of HFCS in the U.S. food supply over the past 40 years appears to be contributing to asthma racial disparities, particularly with higher fructose malabsorption prevalence among Black individuals, relative to other groups, unabsorbed unpaired fructose-induced gut dysbiosis, gut formation of advanced glycation end-products and dysregulation and inactivation of GLP-1 and GIP. Here, GIP is linked to asthma.