To systematically evaluate SIK2 expression patterns in ALS, we analyzed SIK2 levels across different disease stages [35, 36]: the pre‐symptomatic stage (75 days), disease onset (95 days), symptomatic stage (120 days), late‐symptomatic stage (130 days), and end‐stage. Here, SIK2 is linked to amyotrophic lateral sclerosis.