They have been referred to as atypical MSA and FTLD with α‐synuclein pathology (FTLD‐synuclein) and are characterised by (1) varying degrees of FTLD, together with atrophy in striatonigral and/or olivopontocerebellar regions; (2) Gallyas silver‐positive, neuronal cytoplasmic inclusions (NCIs) in cortical and limbic neurones with heterogenous appearance, including Pick body‐like, neurofibrillary tangle (NFT)‐like and ring‐shaped inclusions; and (3) varying amounts of Gallyas silver‐positive α‐synuclein‐immunoreactive glial cytoplasmic inclusions (GCIs). This evidence concerns the gene SNCA and multiple system atrophy.