Among them, 20 AEs of interest were identified, including Rash, Alopecia, Fatigue, Dry skin, Stomatitis, Anorexia, Nausea/Vomiting, Constipation, Myalgia/Arthralgia, Aspartate aminotransferase (AST) increased, Alanine aminotransferase (ALT) increased, Creatinine increased, Anemia, White blood cell decreased, Platelet count decreased, Dyspnea, Pneumonia, Insomnia, Chest pain, and Interstitial lung disease (ILD). The gene discussed is GPT; the disease is insomnia.