Xpert Bladder Cancer Detection is a rapid and noninvasive urine test that detects BCa by analyzing the expression of five mRNA markers (ABL1, ANXA10, UPK1B, CRH, IGF2) using the automated GeneXpert system and RT-PCR technology. The test has a high SN of 78%, especially in high-grade tumors, where SN is 90%, and a high NPV of 98%. Compared to cytology and UroVysion, Xpert offers better results in terms of detecting BCa, making it an effective tool to exclude the disease in patients with hematuria and low risk of BCa. The gene discussed is UPK1B; the disease is urinary bladder cancer.