SHBG and hypothyroidism: The results revealed no increase in the odds of hypothyroidism at the 90th percentile cutoff (OR 1.00, 95% CI 0.29–3.50), but there was an incremental trend toward a 46% increase in the 95th percentile and more than eight times greater odds of hypothyroidism in individuals with SHBG levels ≥ 99th percentile than in those with SHBG levels < 99th percentile (OR 1.46, 95% CI 0.33–6.54; OR 10.07, 95% CI 1.94–52.45, p value = 0.006).