CD274 and melanoma: discovered that the herbal monomer ailanthone could function as a c‐Jun inhibitor by exerting pro‐c‐Jun degradation, directly inhibiting c‐Jun‐induced PD‐L1 expression and secretion, and lowering the level of treg cell infiltration in the tumor microenvironment, improving the therapeutic effect of anti‐pd‐L1 on melanoma [44].