We obtained 20 differentially expressed MAPK‐related genes, of which RASGRP4, DUSP3, HSPA1A, HSPA6, IL1R1, KRAS, MAP3K5, RPS6KA1, BRAF, TNF, CACNA1I, and RPS6KA5 were overexpressed in IDD samples, whereas RASGRP1, DUSP14, DUSP2, RRAS2, JUN, PRKACB, RAP1A, and RAP1B were downregulated (Figure 2A,B). This evidence concerns the gene MAP3K5 and intervertebral disk degenerative disorder.