Renin-angiotensin-aldosterone system (RAAS) blockers and new antidiabetic agents with cardio- and nephroprotective effects (sodium-glucose cotransporter 2 inhibitors (SGLT2i) - and glucagon-like peptide-1 receptor agonists – (GLP-1 RA)) have drastically changed the prognosis of T2DM patients with kidney disease, reducing cardiovascular events and mortality, slowing the decline of eGFR, and delaying the need for renal replacement therapy (21–23). This evidence concerns the gene SLC5A2 and kidney disorder.