The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a pivotal role in breast carcinogenesis, with approximately 70% of breast tumors exhibiting hyperactivation of this pathway (43, 44). Here, AKT1 is linked to breast neoplasm.