Dyshormonogenic congenital hypothyroidism can occur due to loss-of-function mutations in the solute carrier family 5 member 5 (SLC5A5) gene, which is responsible for encoding the NIS.2 The efficacy of radioiodine therapy for TC depends on the process of iodide accumulation in tumor cells, which is facilitated by the NIS. Here, SLC5A5 is linked to congenital hypothyroidism.