As a result, primary tumor size >40 mm, extrathyroidal extension, age >55 years, and early thyroglobulin progression (any increase in thyroglobulin levels 4–6 months after initial treatment) were found to be important risk factors for RAI-refractory thyroid carcinoma disease.10 It has been reported that older patients are at risk of a higher histological phenotype and a higher RAIR rate. Here, TG is linked to thyroid gland carcinoma.