Stable expression of SSTR2 in human PDAC cells, or Sstr2 in hamster PC-1 and PC-1.0 pancreatic cancer cells, led to constitutive activation of SSTR2/Sstr2 and activation of a stable autocrine negative loop that restored the growth inhibitory effect and decreased tumorigenicity. Here, SSTR2 is linked to pancreatic neoplasm.