This inhibits the function of insulin-mediated glucose transporter 4 (GLUT4) and disrupts the downstream phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway, resulting in glucose metabolism imbalance, which further promotes the development of obesity and diabetes (Zhang et al., 2020). This evidence concerns the gene AKT1 and obesity due to melanocortin 4 receptor deficiency.