Fever, headaches, dyspnea, abdominal pain, nauseaNormal physical exam; increased liver enzymes and LDHWBC 25K, L 72%EBV VCA IgG+ IgM+; EBNA+; EA Ab−; EBV DNA−; hepatitis A/B/C virus and Toxo serologies NDHistoplasma Ag serum and urine negativeCT of the chest, abdomen, and pelvis: mediastinal LN, small pleural effusion, gallbladder stones; bone marrow biopsy with T-cell large granular lymphocytes; cholecystectomy with chronic cholecystitis on pathology. Here, CD40LG is linked to Cholecystitis.