The chemokine profiles between these two cancer types reveal notable distinctions: ESCC demonstrates significantly higher expression of CXCL12, CXCR4, and CCL20, which are associated with enhanced tumor invasiveness and metastatic potential, whereas EAC shows a relatively different chemokine signature with increased CCL2 and IL-8 levels. This evidence concerns the gene CXCL12 and esophageal squamous cell carcinoma.