HCC malignancy manifesting as an increase in the expression of Ki-67 is also characterized by abnormal vascular branching patterns of tumor capillaries, an incomplete basal membrane, and blood flow into small, leaky, and poorly efficient tumor capillaries, all of which increase the incidence of leaks and decrease capillary perfusion (11, 24). The gene discussed is MKI67; the disease is hepatocellular carcinoma.