Previous studies have shown that IDH1/2 gene mutation can cause α-ketoglutaric acid reduction and 2-hydroxyglutaric acid increase, indirectly affect angiogenesis, hypoxia stress, cell maturation and differentiation, and other physiological and pathological processes, and interfere with the expression of vascular endothelial growth factor and other tumor-related genes (6, 44). Here, VEGFA is linked to neoplasm.