Hence, studying uncertainties surrounding a) myonectin levels pre and post-exercise intervention in individuals with varying metabolic statuses, b) the impact of exercise duration, c) type of exercise for targeting muscles, and finally, d) myonectin-mediated effects on glucose and insulin resistance in healthy individuals or those at risk for early detection of diabetes, are crucial to deepen our understanding of metabolic linked pathogenesis and identify potential therapeutic exercise targets. This evidence concerns the gene C1QTNF5 and diabetes mellitus.