The search strategy was: [(("Exercise"[MeSH Terms] OR "Physical Activity" OR "Resistance Training" OR "Aerobic Exercise" OR "High-Intensity Interval Training" OR "HIIT") AND ("Myonectin" OR "CTRP15" OR "C1q/TNF-related protein 15" OR "Myokines" OR "Adipokines") AND ("Insulin resistance"[MeSH Terms] OR "Glucose Metabolism" OR "Glycemic Control" OR "Type 2 Diabetes" OR "Metabolic Syndrome") AND ("Overweight"[MeSH Terms] OR "Obesity"[MeSH Terms] OR "Healthy" OR "Lean" OR "Elderly" OR "Normal Weight")) NOT ("Diabetes"))]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.