CD8A and malignant colon neoplasm: In the context of colon cancer, the immune system's dynamics are shaped by the interactions of various immune cell subsets, including CD8+ T cells, CD68+ macrophages, CD23+ B cells, and CD45+ leukocytes, with CD20-expressing B cells and CD5-positive T cells playing key modulatory roles in regulating the immune response and influencing tumor progression [8].