NRP1-mediated angiogenesis in ccRCC and NRP2-driven lymphangiogenesis and tumor invasion in SKCM demonstrate the complexity of TME dynamics, and their shared role in ECM remodelling and cancer immune evasion provides novel insights into effector mechanisms of M2-polarised macrophages in the TME. The gene discussed is NRP1; the disease is nonpapillary renal cell carcinoma.