C1Q genes are products known to promote tumour progression in cancer by interacting with tumour-produced complement system molecules (24)In addition, tumour cells which were predicted to communicate with TAMs through the immune checkpoint HLA-G – LILRB1/2 axis that shows involvement in polarisation into the immunosuppressive M2 phenotype and immune escape of the tumour (25) showed high correlations with NRP1 and NRP2 in the TCGA data of ccRCC (P-value = 2.2e-11) and SKCM (P-value = 3.7e-18) according to the correlation analysis (26). This evidence concerns the gene HLA-G and nonpapillary renal cell carcinoma.