The complexity of NRP2 involvement in SKCM is associated with its co-enrichment with SDC3. It has been shown that SDC3 expression in melanoma TAMs is positively regulated by HIF1α (43), which has also been shown to repress NRP2 promoter activity and expression in another cancer type, lung adenocarcinoma (44). This evidence concerns the gene HIF1A and lung adenocarcinoma.