NRP2 and neoplasm: Upregulation of NRP2 during M2-like polarization and efferocytosis shows the complexity of the roles TAMs may play, as tumours can harness efferocytosis to prevent DAMP-induced inflammation with the high burden of apoptotic cells within a tumour, and phagocytosis itself leads to anti-inflammatory signalling through TGF-β and IL-10 secretion from the phagocyte (45).