To understand the main functions of the rigorously selected 47 NRP1-related DEGs and 91 NRP2-related DEGs upregulated in macrophages from the ccRCC and SKCM samples (threshold > 0.5), Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses on the DEGs were performed. This evidence concerns the gene NRP1 and nonpapillary renal cell carcinoma.