Hereby we confirm certain gene-sets in the NRP isoform-specific manner: CTSL and CTSB are associated with NRP1 in TAM of ccRCC, as well as PLTP, SDC3, and MMP14 which showed elevated expressions coupled with NRP2 in the SKCM samples, adding to the array of effector mechanisms used by TAMs to aid tumour progression, as predicted based on the literature. Here, CTSL is linked to nonpapillary renal cell carcinoma.