Comparative analysis revealed that NRP1+ TAMs in ccRCC were predominantly engaged in lysosome-dependent antigen processing, ECM degradation, and VEGF-mediated angiogenesis, while NRP2+ TAMs in SKCM played a more prominent role in lipid metabolism, immune suppression, and neural-like environment remodelling. The gene discussed is NRP2; the disease is nonpapillary renal cell carcinoma.