The USP7 can stabilize Heterogeneous nuclear ribonucleoprotein A1 in cancer-associated fibroblasts through deubiquitination, leading to increased secretion of exosomal miR-522, thereby inhibiting ferroptosis and promoting acquired drug resistance in GC (169), primarily by targeting arachidonate 15-lipoxygenase and blocking the accumulation of lipid ROS in Mt. The gene discussed is ALOX15; the disease is cancer.