Another study indicates that the PINK1-PARK2 pathway-mediated degradation of SLC25A37 and SLC25A28 increases mitochondrial iron accumulation, leading to HIF-1α dependent Warburg effect and AIM2 inflammasome activation in tumor cells, promoting the release of high mobility group box 1 and further inducing the expression of CD274/PD-L1 (133). The gene discussed is PRKN; the disease is neoplasm.