hnRNPA1 is found to mediate the packaging of miR-522 into exosomes, and USP7 stabilizes hnRNPA1 by deubiquitination. Cisplatin and paclitaxel promote the secretion of miR-522 from cancer-associated fibroblasts (CAFs) by activating the USP7/hnRNPA1 axis, leading to the suppression of ALOX15 and a reduction in lipid-ROS accumulation in cancer cells, ultimately leading to decreased chemotherapy sensitivity. Here, ALOX15 is linked to cancer.