We observed a decrease of Treg cells (CD45+CD4+FoxP3+) in tumor-draining lymph nodes (tdLN) in NPc-Rel-treated mice compared to PBS-treated mice; however, the percentages of the tdLN T helper cells (CD45+CD4+) and cytotoxic T cells (CD45+CD8+) were similar among all groups (Supplementary Figures 7A, B, D). The gene discussed is REL; the disease is neoplasm.