REL and neoplasm: A weak anti-tumor effect of NPc-Rel was noted at 500 pmol/dose (Supplementary Figure 4), and more importantly, a significant reduction in tumor size (418 ± 78 mm3) was observed at 2000 pmol/dose of NPc-Rel as compared to other groups (Figure 3B), indicating a strong and dose-dependent anti-tumor therapeutic effect of c-Rel siRNA-loaded nanoparticles.