In MASH mouse models, elevated hepatic expression of Thioredoxin-interacting protein/Vitamin D3 up-regulated protein 1 (TXNIP/VDUP1) interacts with AMPK to promote mTORC1 inactivation and Transcription factor EB (TFEB) nuclear translocation, thereby enhancing autophagy and fatty acid oxidation, leading to improvement in hepatic steatosis, inflammation, and fibrosis (28) (Figure 2). The gene discussed is TFEB; the disease is fatty liver disease.