In MASH mouse models, elevated hepatic expression of Thioredoxin-interacting protein/Vitamin D3 up-regulated protein 1 (TXNIP/VDUP1) interacts with AMPK to promote mTORC1 inactivation and Transcription factor EB (TFEB) nuclear translocation, thereby enhancing autophagy and fatty acid oxidation, leading to improvement in hepatic steatosis, inflammation, and fibrosis (28) (Figure 2). This evidence concerns the gene TXNIP and fatty liver disease.