ESX1 and Granuloma: Granuloma necrosis, a key pathogenic event, is heavily impacted by the ESX-1 secretion system, as extensively reported in the literature (Clemmensen et al., 2017; Driver et al., 2012; Kramnik, 2008; Pym et al., 2002; Stanley et al., 2007; Swaim et al., 2006; Wassermann et al., 2015).