We used a murine model of TB that more closely represents human pathology by employing the C3HeB/FeJ mouse model and a low-dose aerosol infection model using E2Crimson fluorescently labelled Mtb H37Rv wild type (E2Crimson Mtb WT) and E2Crimson fluorescently labelled Mtb H37Rv ESX-1 deletion mutant (E2Crimson Mtb ΔRD1) (Fig. 1A). This evidence concerns the gene ELF3 and tuberculosis.